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This increases the formation of certain carcinogens such as nicotine-derived nitrosamine ketone (NNK), known to promote adenocarcinoma.[14] Added to this are the more intense inhalations taken by the smoker to compensate for the filtration effect, which cause the smoke to penetrate deep into the lungs, reaching the distal respiratory tract where cells are particularly conducive to adenocarcinoma.[15] In 2014, the surgeon general in the United States concluded that the increase in adenocarcinoma recorded in the country since the 1960s was largely due to the introduction of ventilated filters

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But Moody's analyst Roberto Pozzi said the combined company could use its heft to invest in new products, generate more profit and better manage the risks that come with entering new markets

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This stable raw material availability from a readily renewable base appeals to tobacco manufacturers increasingly sensitive to sustainability concerns