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Furthermore, studies have shown that, as a regulatory mechanism, there is an increase in expression of GLUT1 through activation of phosphoinositide-3 kinase (PI3K)/Akt pathway via hypoxia-inducible factor-1 (HIF-1) (Yeh et al., 2008)

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[3] [4] Born and raised in Boston, Summer dropped out of high school before graduating and began her career as the lead singer of a blues rock band named Crow and moved to New York City

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The Office for National Statistics in the United Kingdom even reported a rise in baby names stolen from characters in the show, particularly the names Arthur, Finn and Tommy