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Less smoking is certainly better than more ("It does reduce harm," says Hackshaw), but it's no match for quitting

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Researchers demonstrated through optogenetic stimulation studies that activation of the GLP-1 receptor in this MHb-IPN circuit eliminates nicotine reward and reduces nicotine intake

The article from Prasse et al suggest[s] that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production]. Osteopontin and cellular receptors for nicotine may therefore be new targets for treating smoking related lung disease

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