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Up to a certain point in history, pretty much everyone smoked, whatever was expected from them physically cigarette ads in the 1960s and earlier were filled with grinning athletes cheerfully sucking on butts

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Feature integration grows, with windproof technology, rechargeability, and multi-function designs (e.g., ashtrays with snuffers) becoming common

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It is important to note that global 5-mC or 5-hmC levels may not necessarily reflect locus/gene-specific patterns of DNA methylation or hydroxymethylation, respectively [222, 227, 228]