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Analyzing the effects on gene expression and DNA methylation that are shared between smoking and aging, the researchers noted that in people who quit smoking, non-reversible DNA methylation sites in the lung were enriched in DNA methylation sites that are associated with aging signatures, but this wasnt the case for reversible and partially reversible sites suggesting that the smoking effects that affect DNA methylation in common to aging are more persistent in time. This was not the case for gene expression changes