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Clear any nasal congestion: Before administering the peptide via spray, clear the nasal membrane

Evaluation of the risk of biases For studies that investigate the effectiveness of coffee enema, the researchers adopted the Cochrane risk of bias tool [9] for randomized controlled trials (RCTs) and the risk of bias assessment tool for nonrandomized studies (Risk of Bias Assessment tool for Nonrandomized Studies [RoBANS])

Nevertheless, these above results suggested novel therapeutic targets for ameliorating clinical symptom of ASD children