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In the legally prescribed International Organization of Standardization measurement method (ISO), in which air is mixed with the smoke through the ventilation holes, the connection is also visible, but less significant

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Many e-cigarette companies dont sell cartridges at strengths higher than 16 mg, which might not be enough for long-term smokers

Further evidence in terms of the efficacy of NRTs, ideally from placebo-controlled RCTs with high rates of compliance with NRT treatment, is needed in order to fully understand the role of NRT in supporting cessation during pregnancy 1

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