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N Engl J Med 332:11981203 Reznick AZ, Cross CE, Hu ML, Suzuki YJ, Khwaja S, Safadi A, Motchnik PA, Packer L, Halliwell B (1992) Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation

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Some are just of poor quality and dont deliver the kind of performance ex-smokers are used to, while others have a series of advanced features that make using them a drag (pun intended) for casual vapers