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151, 152, 153 In addition, mast cells are significant sources of TSLP, which potently enhances allergic sensitization

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Furthermore, recent work in our laboratory has shown down regulation of the tumor suppressor genes notch receptor 1 ( NOTCH1 ) and HECT and RLD domain containing E3 ubiquitin protein ligase 2 ( HERC2 ) in healthy smokers as compared no nonsmokers [176]