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(Evidence Based) Across multiple randomized trials, meta-analyses, and guideline reviewsincluding the ACC , JAMA , Cochrane , and NEJM bupropion SR consistently demonstrates: Higher quit rates than placebo Comparable efficacy to nicotine patch Less effective than varenicline, but with a favorable safety profile Only the SR version has robust clinical data and FDA approval for cessation Dosing Bupropion SR

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