It contains high-performance antioxidant active ingredients that work by down-regulating pathway mechanisms responsible for melanin overproduction
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Notably, with the rapid development of nasal delivery systems, their unique advantage of bypassing the peripheral blood circulation via the olfactory bulb pathway offers an innovative approach to overcoming the physical limitations of the blood-brain barrier and avoiding the first-pass effect in the liver, potentially becoming a key direction for optimizing brain-targeted delivery efficacy in future research [41,42,43]
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Am Rev Respir Dis 148 : 11741178 Schmidt R, Luboeinski T, Markart P, Ruppert C, Daum C, Grimminger F, Seeger W, Gunther A 2004 Alveolar antioxidant status in patients with acute respiratory distress syndrome
