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Abstract The majority of smokers relapse even after successfully quitting because of the craving to smoking after unexpectedly re-exposed to smoking-related cues

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Given that naturally occurring sucrose is typically present in processed tobacco in relatively small amounts, its substantial variability across chewing tobacco brands suggests that sucrose or sucrose-containing additives are used in product manufacturing, with the likely purpose of modifying its taste and potentially other characteristics

So, immunotherapy wont be effective if you dont have enough dendritic cells near the tumor