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Of 153 cases of leprosy treated with dapsone in Nigeria in 1951, seven cases (4.5%) of sulfone syndrome were observed within two months of starting treatment.10 Over the decades, a variety of medications involved in triggering the DRESS syndrome were identified, especially antiepileptic drugs, antibiotics, antituberculosis drugs, and non-steroidal anti-inflammatory drugs (NSAIDs), among others

Use of carrier-mediated transport systems The chemically modified therapeutics (small-molecular drugs) can be used as endogenous transport/carrier systems

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Functional Half-Life is a Meaningful Descriptor of Steady-State Pharmacokinetics of an Extended-Release Formulation of a Rapidly Cleared Drug

[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Xu Z, Li X, Yang Z, Zhang Z, Zhang Y, Fan M, Zeng Y, Kang M, Shen Y, Wang D, et al