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The evidence base consists entirely of preclinical animal studies and in vitro research on vascular repair mechanisms

In addition, various coating materials like polyethylene glycol (PEG), poly (lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), lipids, and others have been used to modify the metal-based NP surface, which considerably changes the physicochemical properties of NPs (Tefft et al., 2015

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NAD+ supports metabolism, DNA repair, cell defenses, circadian rhythm coordination and other cellular processes which leads to better quality of life