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The Grip of Addiction: Nicotine's Impact on the Brain Nicotine addiction alters brain chemistry, creating a powerful dependency

He (probably falsely) claims he won't last 5 minutes, but nobody will break the agreement by giving him a cigarette

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Mental effects may include loss of contact with reality, an intense feeling of happiness, or agitation

What they neglect to point out, however, is that George Harrison is wearing denim the color of mourning in Canada