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For example, the product label for Xanax , which is prescribed as a tranquilizer, indicates the drug has an average half-life of 11.2 hours (i.e., the length of time for half of the dosage of the drug to be metabolized), with a range of 6.3 to 26.9 hours in healthy adults

The methodology was based on comparing the therapeutic index of the substances, which was defined as the ratio of the median lethal dose (LD50) to the median effective dose (ED50)

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