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We, therefore, modeled the majority part of the c-MET extracellular domain (all domains except for IPT3 and IPT4) as well as the majority part of HGF (all domains except for K3 and K4) by using the cryo-EM structure of sub-complex that was determined at higher resolution, with the help of the available crystal structures of different domains of c-MET and HGF 14,24,25 (Supplementary Fig