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Forecast model & key assumptions Every forecast includes explicit documentation of: Key growth drivers and their assumed impact Restraining factors and mitigation scenarios Regulatory assumptions and policy change risk Technology adoption curve parameter Macroeconomic assumptions (GDP growth, inflation, currency) Competitive dynamics and market entry/exit expectations 6

Further studies are needed to elucidate the detailed mechanisms by which smoking induces endothelial dysfunction and to determine whether smoking cessation directly improves endothelial function

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