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By increasing NAD levels and activating the SIRT1 pathway, NNMTi inhibits the activation of inflammatory signaling pathways (such as the NFB pathway), thereby reducing macrophage infiltration and inflammatory factor release

The practical takeaway: AOD-9604 has a clean safety profile in trials but a failed Phase 2b efficacy endpoint

Not for Human Consumption, For Research Use Only

Secondary osteoporosis: obesity, diabetes, long-term sedentary, hormone drugs, excessive fat reduction, etc., interfere with calcium and phosphorus metabolism, inhibit osteogenesis, promote osteoclasis, and cause bone loss

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