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doi: 10.7326/0003-4819-119-9-199311010-00003 2 AllaisL.KerckhofF

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A polygenic risk score (PRS) indicates cumulative genetic propensity using multiple risk alleles identified by genome-wide association studies (GWAS) 15

They have a function in host defence and play a significant role in airway inflammation by releasing NO, a potentially important mediator of airway inflammation [13, 14], as well as releasing other mediators and recruiting inflammatory cells [12, 15, 16]

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