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People with serious mental illness and substance use disorders smoke at far higher rates than the general population and die disproportionately of tobacco-related disease addressing nicotine during SUD treatment is increasingly standard of care rather than an afterthought

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Analytical grade chemicals nitrone spin trap phenyl- N - tert -butylnitrone (PBN), tert -butylbenzene, (2,2,6,6-tetramethyl-piperidin-1-yl)oxyl (TEMPO), and 1- 1-oxidanyl-2,2,6,6-tetramethyl-piperidin-4-ol (TEMPOL) were obtained from Sigma-Aldrich (St