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These pouches are used by placing them in the mouth, where they release nicotine through the mucous membranes into the bloodstream

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Cinnamaldehyde (the compound imparting cinnamon flavor) is a prominent example: inhalation of cinnamon-flavored e-cigarette aerosol has been shown to damage airway epithelial cells and suppress pulmonary immune cell function, impairing alveolar macrophages ability to clear pathogens (45)