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Glutathione faces absorption challenges when taken orally, as it's often broken down in the digestive system

This question nevertheless remains open and requires specific investigation

GSH is a tripeptide synthesized in the cell cytosol from the amino acids precursors: glutamate, cysteine, and glycine, by two ATP-requiring enzymes: glutamate-cysteine ligase (GCL) and GSH synthetase (GSS)

Clinical Pharmacology & Therapeutics, 106, 88490

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