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Marienne is likable

Qi X, Ng KT, Lian Q, Li CX, Geng W, Ling CC, Yeung WH, Ma YY, Liu XB, Liu H, et al

There is only the case of the nuclear transcription factor c-Jun that, due to an unusual redox potential, could react with GSSG at relatively high ratio of GSH/GSSG = 13 ( S -glutathionylation within the cells involves reaction of the critical cysteine on protein or GSH with a corresponding oxidized derivative such as S-nitrosyl ( S -NO), sulfenic acid ( S -OH), thiyl radical ( S )

Lactate accumulation acidifies the microenvironment, exacerbating ion dyshomeostasis and attracting neutrophil extracellular traps, web-like DNA structures that entangle MMP-9, amplifying BBB leakage [156] (Fig

This indicates substantial phenotypic heterogeneity and suggests that metabolic factors likely act as potent disease accelerants in genetically or biomechanically susceptible individuals, rather than being universal initiators (34)