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Opioids may suppress testosterone and alter HPA-axis function, while corticosteroids alter cortisol rhythms

Int J Nanomed 13:30393051

Cervicovaginal dysbiosis is thought to exacerbate this process by potentially facilitating HPV acquisition and persistence, and promoting viral transformation (including E6/E7 expression, viral integration, and genomic instability), and supporting secondary infections, such as those caused by Chlamydia trachomatis (Figure 3)