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It was also reported the effect of flavokavain A in the extrinsic and intrinsic apoptosis pathways, since it can upregulate Bim, p23, DR5 and Bax and downregulate Ki67, survivin and XIAP in a dose-dependent manner [108,110,111]

Their impaired function leads to increased oxidative damage and subsequent immune cell and NLRP3 inflammasome activation [54]

Absorption problems

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