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Bupropion (Zyban) : Originally developed as an antidepressant, bupropion reduces withdrawal symptoms and craving through effects on dopamine and norepinephrine systems

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1988 Reducing the Health Consequences of Smoking: 25 Years of Progress: A Report of the Surgeon General US Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health: Rockville, MD US Department of Health and Human Services

Europe represents a mature tobacco market experiencing structural volume declines due to stringent tobacco control measures, decreasing smoking prevalence, and robust public health initiatives

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