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Lastly, during combined hyperglycemia and hyperinsulinemia platelets increase expression of CD40L, which interacts with monocytes and endothelial cells inducing a cascade of inflammatory responses including tissue factor (TF) expression [42]

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Their immunoregulatory functions involve interactions with immune cells through adhesion molecules and soluble factors 10 , resulting in the secretion of cytokines like TNF-, TGF-B, IL6, and IL8 12

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It has retreated from a recent maximum of 29 km (18 mi) in the 1960s