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These insights lay the foundation for developing novel therapies targeting energy metabolism in neurodegenerative and metabolic brain conditions, with further preclinical studies planned to assess safety and efficacy

Safety Note: Subjects should start with lower doses (0.2 mg of each compound) to assess individual tolerance

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These in vivo data demonstrate that the primary role of skeletal IGF-1 is for the terminal differentiation of osteoprogenitors, but refute the role of IGF-1 in MSC migration in vivo