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Mutations in KDSR cause recessive progressive symmetric erythrokeratoderma

Inhalation of smoke primarily causes carbon monoxide and hydrogen cyanide poisoning, leading to severe toxic symptoms

Epidemiology 27(3):395404 Thun MJ, Carter BD, Feskanich D, Freedman ND, Prentice R, Lopez AD et al (2013) 50-year trends in smoking-related mortality in the United States