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Bowden N, Gibb S, Thabrew H, Kokaua J, Audas R, Merry S, et al

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During adolescence, it is widely accepted that DA systems actively mature, whereas 5-HT systems exhibit comparatively low developmental activity since 5-HT neurons are among the first to mature during early brain development ( 4.1 Serotonin signaling through 5-HT 1A Rs regulates adolescent DA-mediated behaviors Brief nicotine pretreatment during early adolescence has been shown to uniquely enhance DA-mediated behaviors, including cocaine self-administration, conditioned place preference, and locomotor sensitization as well as ambulatory activity induced by the D 2 receptor agonist, quinpirole ,3236

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