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We systematically tested for the effect of bias covariates using metaregression, selected significant bias covariates using the Lasso approach 194,195 and adjusted for the selected bias covariates in the final risk curve
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[DOI] [PubMed] [Google Scholar] 217
When faced with secession in 1861, Southwestern Virginia politicians chose to stay loyal to the leaders in Richmond rather than join the new state of West Virginia, in large part because of economic and social ties that developed in the 1850's as the region adopted tobacco as a cash crop
