The histidine residue provides the primary copper-binding site through its imidazole nitrogen, with additional coordination from the peptide backbone and the amino terminus
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Visible results as early as 7 days
Together, these primary data delineate a pathogenic axis spanning focal iron accumulation, peripheralcentral iron imbalance, and ferroptosis susceptibility in early AD. Further evidence shows that ferritin levels in cerebrospinal fluid (CSF) can predict the rate of cognitive decline and are significantly associated with both A-positivity on PET imaging and elevated t-Tau concentrations
Talchai, C., Xuan, S., Lin, H
