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The extraction process uses real tobacco leaves rather than synthetic flavor compounds

Although the underlying mechanisms by which arsenic causes such oxidative damage are not yet fully understood, possible mechanisms could include inhibition of antioxidant enzymes such as superoxide dismutase (SOD) and catalase, interface with cellular antioxidant defense systems by reducing levels of intracellular antioxidants such as glutathione, inhibition of DNA repair mechanisms, and alterations in epigenetic processes [7]

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The plants are susceptible to an army of pests

If you like really heavy, high nicotine, perique mixtures, you might like this, particularly if you enjoy dizziness and nausea