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Digoxin Digoxin toxicity (high levels) is demonstrated in 10% of patients and toxicity has been reported in 4% of a series of 4 000 digoxin samples assayed

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Compared to L-arginine, an advantage to supplementation with L-citrulline is that intestinal catabolism of L-citrulline is limited since it is not metabolized by arginases, and the activity of arginosuccinate synthase is low in enterocytes [2]

All of these data present RESV as a promising therapeutic strategy for PE and FGR, although clinical studies in PE and FGR with RESV are currently very limited