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The CNS GLP- 1 receptors are not necessary for the physiological regulation of blood glucose levels by endogenous GLP- 1 or the pharmacological control of glucose homeostasis that depends on GLP- 1 receptors, although further research is needed to investigate the possible role of GLP- 1 receptors expressed outside the beta cell, including within the enteric and peripheral nervous systems, in improving beta cell function through enteral glucose mediation [70, 84]

Cho, E.S

Notably, eight other fluoroquinolones (Levofloxacin, Gatifloxacin, Ofloxacin, Moxifloxacin, Marbofloxacin, Sparfloxacin, Perfloxacin and Norfloxacin), some of which are reported as radioprotectors 90 , were not hits in our drug screen (Supplementary Data 1)

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This damage not only contributes to the diseases initiation but also activates inflammatory signaling pathways, further amplifying the inflammatory cascade