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Thus, the levels of the pro-inflammatory cytokines TNF, IL-1 , IL-6, IL-12, and IL-13 were elevated, whereas the levels of the anti-inflammatory cytokine IL-10 were reduced, in the lungs of exposed mice [115, 116]

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In fact, on the original anime original side, it is said that Nami can't eat a mess made by Apis.[73] Considering that in real life there have been cases of people being arrested for putting narcotic substances in their food to attract customers, it seems like they really dislike making their food taste good by forcing it through strange expedient methods.[74] Therefore, the part where Sanji put a razor in Zoro's lunchbox in the Punk Hazard episode was harshly criticized by some readers, calling it a rare character breakdown

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