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Underdosing is the most common reason for suboptimal outcomes

In one study, one-third to two-thirds of the weight lost using lifestyle interventions was regained within 1 year following the end of treatment, and greater than 95% of the weight was regained within 5 years

10.1007/s00441-017-2738-1 Cell Tissue Res

These effects were counteracted by stable gastric pentadecapeptide BPC 157

[128:22] Andrew Huberman And in species like dogs, where there's tremendous variation in the amount of IGF one that's made between, say, a Chihuahua and a Great Dane, the breed that makes more IGF1 downstream growth hormone, of course, lives a lot shorter lives than smaller versions of the same species