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Vincent van Gogh, Public domain, via Wikimedia Commons Van Goghs skull might be seen as van Goghs first self-portrait a caustic, harsh remark on an unkempt and unappealing look that had been an expression of unity with the villagers in Nuenen but became a source of shame and an issue in the metropolis

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Genetic factors Genetic factors also play a role in the development of COPD and may accelerate a decline in lung function