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Nuclear gene mutations, such as peroxisome proliferator-activated receptor gamma coactivator (PGC-1) (regulating mitochondrial biogenesis) or isocitrate dehydrogenase (IDH)1/2 [affecting accumulation of the metabolite, 2-hydroxyglutarate (HG)], drive tumor progression through epigenetic or metabolic reprogramming 26
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Crack users generate higher levels of these metabolites due to the intense dosing
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Youd also be hard-pressed to find a golfer more aware of the importance of glucose homeostasis
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