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Herceptin Hylecta (trastuzumab/hyaluronidase, Roche/Genentech), Rituxan Hycela (rituximab hyaluronidase, Roche/Genentech), Darzalex Faspro (daratumumab/hyaluronidase, Janssen) and Phesgo (pertuzumab/trastuzumab/hyaluronidase, Roche/Genentech) are examples of SC administered drugs exceeding 2 mL using hyaluronidase co-formulations

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A subset of patients on standard NHS maintenance feel their symptoms return well before the next scheduled injection

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Its activity is mediated through copper transport, gene modulation, and interaction with extracellular matrix components

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