According to the report by CDC (Centers for Disease Control and Prevention), published on June 23, 2023, between April 2022 and March 2023, there were 7,043 reported cases of e-cigarette exposure, a 32% increase
however, in the main analysis using expected rates based on linear regression models, this proportion was substantially higher in the White population
"Our analyses show that there is significant toxicity in harm reduction products, and reduction of carcinogens in harm reduction mainstream smoke does not necessarily reduce the toxicity of unfiltered sidestream smoke." Researchers developed tests with human embryonic stem cells, which are similar to young embryos, to compare the toxicity of mainstream (inhaled) smoke and sidestream smoke from both conventional and harm reduction cigarette brands
Abbreviations AR: Androgen receptor CS: Cigarette smoke ECARs: Extracellular acidification rates EGFR: Epidermal growth factor receptor GEO: Gene expression omnibus HIF-1: Hypoxia-inducible factor 1 HPAEC: Human pulmonary artery endothelial cell IGF-1: Insulin-like growth factor-1 IPA: Ingenuity pathway analysis M-CSF: Macrophage colony-stimulating factor MMP-2: Matrix metalloproteinase-2 MMP-9: Matrix metalloproteinase-9 NT-4: Neurotrophin-4 OCR: Oxygen consumption rates PDGF-AA: Platelet-derived growth factor-AA SA--Gal: Senescence-associated -galactosidase TGF3: Transforming growth factor 3 VEGFR3: Vascular endothelial growth factor receptor 3 2-DG: 2-Deoxyglucose References Borgerding M, Klus H
A decade of research on vaping has answered some of the questions about e-cigarettes' relative harm: this report will summarize what findings have been established conclusively, what needs to be researched further and what this evidence means for the future
