Bad bugs, no drugs: no ESKAPE
I/R reduces nitric oxide bioavailability while increasing vasoconstrictors such as endothelin-1, angiotensin II, and thromboxane A, leading to sustained vasoconstriction and impaired autoregulation of renal blood flow (Brooks 1996
It is particularly useful for sluggish liver function caused by fatty diet or alcohol exposure
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In the end, this can hold a general counteracting potential and contributing innate neurotransmitter potential, matching with the original cytoprotection concept perception holding equal cell protection (necrosis prevention) against a variety of different agents, thus, a pleiotropic beneficial effects that should be obtained with cytoprotective agents application that could also have neurotransmitter background as well
