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Not used very often today Dosages Qd at night bid, qid Mechanism of Action Blocks H2 receptors on parietal cells of the stomach Reduces volume of gastric juice and hydrogen ion content Works on basal phase at night Uses Gastric and duodenal ulcers relieve pain, promote healing, prevent recurrence o prevent complications Gastroesophageal reflux disease (GERD) Treatment of Zollinger-Ellison syndrome Aspiration pneumonitis Heartburn, acid indigestion, and sour stomach Adverse Effects Significant side effects are uncommon Antiandrogenic effects (gynecomastia, reduced libido, and impotence Confusion, hallucinations, CNS depression or excitation Pneumonia Avoid cigarettes ASA, NSAIDS No Alcohol Antacids should not be given within 1 hour of an H2receptor antagonist beca effectiveness may be decreased due to reduced absorption.
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