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While oral glutathione supplements can be largely broken down by the digestive system, making them less effective, IV therapy delivers glutathione directly into the bloodstream, reaching target cells in much higher concentrations

Cancer Gene Ther 3:11-17, 1996

Examples include protein-based nanoparticles made from whey protein isolate (51, 52), zein (corn protein) (53, 54), or casein (55, 56), and polysaccharide-based systems using chitosan (57), alginate (58, 59), or pectin (60, 61)

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Both support the same biological endpoint -- higher intracellular glutathione -- at different points in the pathway (precursor supply vs direct delivery)