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6 Aging leads to a decrease in neuronal mitochondrial [NADH] that is restored in vitro by cysteine supplementation Fluorescence lifetime measurement (FLIM) studies have shown that a decrease in mitochondrial NADH abundance occurs in cultured neurons from aged mice compared to that from young adult mice, which likely indicates an oxidation of the mitochondrial [NAD + ]/[NADH] in aged neurons (Pawlosky et al., 2017) could be the reduction of the mitochondrial [NAD + ]/[NADH]

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Catalase has the highest turnover of all the enzymes and is capable of degrading millions of H 2 O 2 molecules per second