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HFHC group mice were additionally treated with caffeine (75 mg/kg) or EGCG (100 mg/kg) for 6 weeks, using obeticholic acid (OCA,10 mg/kg) as a positive control group

Metabolic Summary Glutamine is both a carrier of ammonia and a carbon backbone used in metabolism when converted to -ketoglutarate

For instance, treatment of subarachnoid hemorrhage with bone marrow mesenchymal stem cells resulted in upregulation of CHAC1/BOTCH , which significantly reduced neuroinflammation by blocking NOTCH1 signaling (Li et al., 2019

Hardy T, Oakley F, Anstee QM, Day CP (2016) Nonalcoholic fatty liver disease: pathogenesis and disease spectrum

Phosphorylated CREB binds DNA at CRE sequences activating genes supporting neuronal survival, plasticity, and function