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Niacin, a closely related form of vitamin B3, is known to transiently impair insulin sensitivity and raise blood glucose levels

In turn, LATS1/2 phosphorylate YAP/TAZ to inactivate them, promoting their cytoplasmic localization [86]

A larger double-blind, placebo-controlled, multicenter trial targeting aging with metformin plans to enroll 3000 patients between the ages of 65 and 79 as the primary endpoint before any aging-related diseases develop

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3.2.3.2 Caffeic acid phenethyl ester (CAPE) CAPE, a natural antioxidant, possesses beneficial roles in cadioprotective, neuroprotective and renoprotective effects (Trumbeckaite et al., 2017