10.1089/hum.2022.013 11 DormondE.ChahalP.BernierA.TranR.PerrierM.KamenA
Mother INP 2.0 #Lichens #SecondaryMetabolites #SymbioticChemistry #UsnicAcid #AntiInflammatory #RespiratoryHealth #SkinHealth #ChronicConditions #INP2_0 #BioinspiredMedicine #NaturalIntelligence To view or add a comment, sign in Structureactivity relationships and roles of Phytochemicals in plants and therapeutics Key elements include functional groups, ring systems, substitution patterns, and stereochemistry, which together govern target binding, potency, selectivity, and ADME Functional groups (hydroxyl, carbonyl, methoxy, glycosidic linkages) and threedimensional arrangement (chiral centers, cis/trans geometry, conjugation) are critical determinants of receptor interaction, redox properties, and membrane permeability
There are two common approaches
Devireddy AR, Tschaplinski TJ, Tuskan GA, Muchero W, Chen JG
Crystallographic analysis of the binding of NADPH, NADPH fragments, and NADPH analogues to glutathione reductase