Interestingly, we observed different phenotypes with the same clonotype indicating the transformation from effector to long-lasting tissue resident phenotype as a consequence of chronic antigen exposure ( Supplementary Figure 1E, F ) ( SCM ) phenotypes that were enriched in people with T1D compared to controls ( + T-cells that display memory and effector memory phenotypes with markers of tissue residency ( RM , expressing CD127 (a marker of long-lived memory and antigen-independent replication), with no features of exhaustion and no CD57 expression, also expressing high levels of PD-1, GzmB, CD101, CD49a and CD103 compared to those in the peripheral lymph nodes (PLN) ( + T RM cells were more abundant in people with diabetes
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[DOI] [PubMed] [Google Scholar] Rasmussen JB, Glennow C
